TSC1 Antibody (PACO13475)
- SKU:
- PACO13475
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | TSC1 Antibody (PACO13475) |
抗体コード: | PACO13475 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human hamartin |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | tuberous sclerosis 1;TSC1;KIAA0243;LAM;MGC86987;TSC ; |
UniProt Protein Function: | TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Tumor suppressor Chromosomal Location of Human Ortholog: 9q34 Cellular Component: TSC1-TSC2 complex; protein complex; growth cone; intracellular membrane-bound organelle; membrane; lamellipodium; cytoplasm; plasma membrane; actin filament; cell cortex; cytosol Molecular Function:protein binding; chaperone binding; protein N-terminus binding; GTPase activating protein binding; GTPase regulator activity Biological Process: myelination; protein heterooligomerization; regulation of cell-matrix adhesion; regulation of cell cycle; cell-matrix adhesion; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; regulation of phosphoprotein phosphatase activity; cardiac muscle cell differentiation; response to insulin stimulus; regulation of translation; negative regulation of cell proliferation; cell projection organization and biogenesis; positive regulation of focal adhesion formation; synapse organization and biogenesis; kidney development; cell cycle arrest; potassium ion transport; negative regulation of TOR signaling pathway; protein stabilization; hippocampus development; rRNA export from nucleus; negative regulation of translation; regulation of stress fiber formation; glucose import; neural tube closure; insulin receptor signaling pathway; cerebral cortex development; regulation of protein kinase activity Disease: Lymphangioleiomyomatosis; Focal Cortical Dysplasia Of Taylor; Tuberous Sclerosis 1 |
NCBI Summary: | This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] |
UniProt Code: | Q92574 |
NCBI GenInfo Identifier: | 9297077 |
NCBI Gene ID: | 7248 |
NCBI Accession: | Q92574.2 |
UniProt Secondary Accession: | Q92574,Q5VVN5, B7Z897, |
UniProt Related Accession: | Q92574 |
Molecular Weight: | 124,015 Da |
NCBI Full Name: | Hamartin |
NCBI Synonym Full Names: | tuberous sclerosis 1 |
NCBI Official Symbol: | TSC1 |
NCBI Official Synonym Symbols: | LAM; TSC |
NCBI Protein Information: | hamartin; tumor suppressor; tuberous sclerosis 1 protein |
UniProt Protein Name: | Hamartin |
UniProt Synonym Protein Names: | Tuberous sclerosis 1 protein |
Protein Family: | Hamartin |
UniProt Gene Name: | TSC1 |
UniProt Entry Name: | TSC1_HUMAN |