TRIM2 Antibody (PACO12906)
- SKU:
- PACO12906
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TRIM2 Antibody (PACO12906) |
抗体コード: | PACO12906 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human TRIM2 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | tripartite motif-containing 2;TRIM2;KIAA0517;RNF86 ; |
UniProt Protein Function: | TRIM2: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Belongs to the TRIM/RBCC family. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: cytoplasm Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: regulation of neuron apoptosis Disease: Charcot-marie-tooth Disease, Axonal, Type 2r |
NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
UniProt Code: | Q9C040 |
NCBI GenInfo Identifier: | 21363034 |
NCBI Gene ID: | 23321 |
NCBI Accession: | Q9C040.1 |
UniProt Secondary Accession: | Q9C040,O60272, Q9BSI9, Q9UFZ1, D3DP09, |
UniProt Related Accession: | Q9C040 |
Molecular Weight: | 84,545 Da |
NCBI Full Name: | Tripartite motif-containing protein 2 |
NCBI Synonym Full Names: | tripartite motif containing 2 |
NCBI Official Symbol: | TRIM2 |
NCBI Official Synonym Symbols: | CMT2R; RNF86 |
NCBI Protein Information: | tripartite motif-containing protein 2 |
UniProt Protein Name: | Tripartite motif-containing protein 2 |
UniProt Synonym Protein Names: | E3 ubiquitin-protein ligase TRIM2; RING finger protein 86 |
Protein Family: | Tripartite motif-containing protein |
UniProt Gene Name: | TRIM2 |
UniProt Entry Name: | TRIM2_HUMAN |