TRIB3 Antibody (PACO17313)
- SKU:
- PACO17313
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | TRIB3 Antibody (PACO17313) |
抗体コード: | PACO17313 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Full length fusion protein |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17313(TRIB3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17313(TRIB3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. |
シノニム: | tribbles pseudokinase 3 |
UniProt Protein Function: | TRB3: a Ca(2)/calmodulin-dependent protein kinase of the Trbl family. Induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. May negatively regulate the cell survival kinase AKT1. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; CAMK group; Trbl family Chromosomal Location of Human Ortholog: 20p13-p12.2 Cellular Component: nucleoplasm; plasma membrane; cytosol; nucleus Molecular Function:protein binding; protein kinase inhibitor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity; kinase activity; transcription corepressor activity; protein kinase binding; ATP binding Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of protein binding; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; protein amino acid phosphorylation; cellular response to insulin stimulus; regulation of MAP kinase activity; positive regulation of ubiquitin-protein ligase activity; insulin receptor signaling pathway; negative regulation of protein kinase activity; innate immune response; negative regulation of transcription, DNA-dependent; negative regulation of fatty acid biosynthetic process |
NCBI Summary: | The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q96RU7 |
NCBI GenInfo Identifier: | 28201830 |
NCBI Gene ID: | 57761 |
NCBI Accession: | Q96RU7.2 |
UniProt Related Accession: | Q96RU7 |
Molecular Weight: | 35kDa |
NCBI Full Name: | Tribbles homolog 3 |
NCBI Synonym Full Names: | tribbles pseudokinase 3 |
NCBI Official Symbol: | TRIB3 |
NCBI Official Synonym Symbols: | NIPK; SINK; TRB3; SKIP3; C20orf97 |
NCBI Protein Information: | tribbles homolog 3 |
UniProt Protein Name: | Tribbles homolog 3 |
UniProt Synonym Protein Names: | Neuronal cell death-inducible putative kinase; SINK; p65-interacting inhibitor of NF-kappa-B |
Protein Family: | Tribbles |
UniProt Gene Name: | TRIB3 |
UniProt Entry Name: | TRIB3_HUMAN |
Antibodies | ELISA Kits |
Anti-TRIB3 Antibody (CAB5424) | Human TRIB3 / Tribbles homolog 3 ELISA Kit |
TRIB3 Antibody (PACO12901) | Human Tribbles homolog 3 (TRIB3) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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