TPH2 Antibody (PACO50758)
- SKU:
- PACO50758
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TPH2 Antibody (PACO50758) |
抗体コード: | PACO50758 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human Tryptophan 5-hydroxylase 2 protein (44-225AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO50758 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO50758 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO50758 at dilution of 1:100. |
バックグラウンド: | cytosol, indolalkylamine biosynthetic process |
シノニム: | Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2), TPH2, NTPH |
UniProt Protein Function: | TPH2: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.14.16.4; Amino Acid Metabolism - tryptophan Chromosomal Location of Human Ortholog: 12q21.1 Cellular Component: cytosol Biological Process: indolalkylamine biosynthetic process Disease: Attention Deficit-hyperactivity Disorder, Susceptibility To, 7; Major Depressive Disorder |
NCBI Summary: | This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q8IWU9 |
NCBI GenInfo Identifier: | 30580625 |
NCBI Gene ID: | 121278 |
NCBI Accession: | Q8IWU9.1 |
UniProt Secondary Accession: | Q8IWU9,Q14CB0, A6NGA4, |
UniProt Related Accession: | Q8IWU9 |
Molecular Weight: | 56,242 Da |
NCBI Full Name: | Tryptophan 5-hydroxylase 2 |
NCBI Synonym Full Names: | tryptophan hydroxylase 2 |
NCBI Official Symbol: | TPH2 |
NCBI Official Synonym Symbols: | NTPH; ADHD7 |
NCBI Protein Information: | tryptophan 5-hydroxylase 2 |
UniProt Protein Name: | Tryptophan 5-hydroxylase 2 |
UniProt Synonym Protein Names: | Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2 |
Protein Family: | Tryptophan 5-hydroxylase |
UniProt Gene Name: | TPH2 |
UniProt Entry Name: | TPH2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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