TNFRSF6B Antibody (PACO21053)
- SKU:
- PACO21053
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TNFRSF6B Antibody (PACO21053) |
抗体コード: | PACO21053 |
サイズ: | 100ul(100ug) |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant protein of human TNFRSF6B |
憲法: | Liquid |
ストレージバッファ: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of 293 cell lysate using TNFRSF6B antibody. |
バックグラウンド: | The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acid, termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity. |
シノニム: | TNFRSF6B;DCR3; TR6 |
UniProt Protein Function: | TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20q13.3 Cellular Component: extracellular space Molecular Function:protein binding; receptor activity Biological Process: apoptosis; negative regulation of apoptosis |
NCBI Summary: | This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011] |
UniProt Code: | O95407 |
NCBI GenInfo Identifier: | 14790170 |
NCBI Gene ID: | 8771 |
NCBI Accession: | NP_116563.1 |
UniProt Related Accession: | O95407 |
Molecular Weight: | 32,680 Da |
NCBI Full Name: | |
NCBI Synonym Full Names: | TNF receptor superfamily member 6b |
NCBI Official Symbol: | TNFRSF6B |
NCBI Official Synonym Symbols: | M68; TR6; DCR3; M68E; DJ583P15.1.1 |
NCBI Protein Information: | tumor necrosis factor receptor superfamily member 6B |
UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 6B |
UniProt Synonym Protein Names: | Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68 |
Protein Family: | Tumor necrosis factor receptor superfamily |
UniProt Gene Name: | TNFRSF6B |
UniProt Entry Name: | TNF6B_HUMAN |
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