TLR6 Antibody (PACO19292)
- SKU:
- PACO19292
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | TLR6 Antibody (PACO19292) |
抗体コード: | PACO19292 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human TLR6 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19292(TLR6 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19292(TLR6 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations. |
シノニム: | toll-like receptor 6 |
UniProt Protein Function: | TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 4p14 Cellular Component: Golgi apparatus; integral to plasma membrane; lipid raft; phagocytic vesicle membrane; plasma membrane Molecular Function:protein binding; receptor activity; transmembrane receptor activity Biological Process: activation of NF-kappaB-inducing kinase; defense response to bacterium; detection of diacylated bacterial lipoprotein; immune response; inflammatory response; innate immune response; interleukin-1 beta secretion; MyD88-dependent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK activity; regulation of cytokine secretion; signal transduction; T-helper 1 type immune response; toll-like receptor 6 signaling pathway; toll-like receptor signaling pathway |
NCBI Summary: | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011] |
UniProt Code: | Q9Y2C9 |
NCBI GenInfo Identifier: | 296452933 |
NCBI Gene ID: | 10333 |
NCBI Accession: | Q9Y2C9.2 |
UniProt Secondary Accession: | Q9Y2C9,Q2NKL3, B3Y640, B6CH35, B6RFS4, B6RFS5, |
UniProt Related Accession: | Q9Y2C9 |
Molecular Weight: | 55,828 Da |
NCBI Full Name: | Toll-like receptor 6 |
NCBI Synonym Full Names: | toll like receptor 6 |
NCBI Official Symbol: | TLR6 |
NCBI Official Synonym Symbols: | CD286 |
NCBI Protein Information: | toll-like receptor 6 |
UniProt Protein Name: | Toll-like receptor 6 |
UniProt Synonym Protein Names: | CD_antigen: CD286 |
UniProt Gene Name: | TLR6 |
UniProt Entry Name: | TLR6_HUMAN |
Antibodies | ELISA Kits |
Anti-TLR6 Antibody (CAB8185) | Human Toll-like receptor 6 (TLR6) ELISA Kit |
TLR6 Antibody (PACO03219) |
Secondary Antibody |
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