TIE1 Antibody, Biotin conjugated (PACO53401)
- SKU:
- PACO53401
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | TIE1 Antibody, Biotin conjugated (PACO53401) |
抗体コード: | PACO53401 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Tyrosine-protein kinase receptor Tie-1 protein (217-328AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. |
シノニム: | Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1), TIE1, TIE |
UniProt Protein Function: | TIE1: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Tie family Chromosomal Location of Human Ortholog: 1p34-p33 Cellular Component: integral to plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: negative regulation of angiogenesis; peptidyl-tyrosine phosphorylation; response to retinoic acid; in utero embryonic development; mesoderm development; angiogenesis; signal transduction; vasculogenesis; negative regulation of cell migration; plasma membrane fusion |
NCBI Summary: | This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | P35590 |
NCBI GenInfo Identifier: | 4885631 |
NCBI Gene ID: | 7075 |
NCBI Accession: | NP_005415.1 |
UniProt Related Accession: | P35590 |
Molecular Weight: | 125,090 Da |
NCBI Full Name: | tyrosine-protein kinase receptor Tie-1 isoform 1 |
NCBI Synonym Full Names: | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
NCBI Official Symbol: | TIE1 |
NCBI Official Synonym Symbols: | TIE; JTK14 |
NCBI Protein Information: | tyrosine-protein kinase receptor Tie-1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 |
UniProt Protein Name: | Tyrosine-protein kinase receptor Tie-1 |
UniProt Gene Name: | TIE1 |
UniProt Entry Name: | TIE1_HUMAN |