TIA1 Antibody (PACO43591)
- SKU:
- PACO43591
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TIA1 Antibody (PACO43591) |
抗体コード: | PACO43591 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IP |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000 |
反応性: | Human |
免疫原: | Recombinant Human Nucleolysin TIA-1 isoform p40 protein (1-193AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: Nucleolysin TIA-1 isoform p40 antibody at 2µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: K562 whole cell lysate. Lane 3: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 43, 42, 25 kDa. Observed band size: 43 kDa. | |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO43591 at dilution of 1: 100. | |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO43591 at dilution of 1: 100. |
バックグラウンド: | Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. |
シノニム: | Nucleolysin TIA-1 isoform p40 (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1), TIA1 |
UniProt Protein Function: | TIA1: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Translation; RNA-binding Chromosomal Location of Human Ortholog: 2p13 Cellular Component: nucleoplasm; stress granule; cytoplasm Molecular Function:protein binding; nucleotide binding; AU-rich element binding; poly(A) binding Biological Process: regulation of nuclear mRNA splicing, via spliceosome; apoptosis; negative regulation of translation; negative regulation of cytokine biosynthetic process Disease: Welander Distal Myopathy |
NCBI Summary: | The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017] |
UniProt Code: | P31483 |
NCBI GenInfo Identifier: | 206729905 |
NCBI Gene ID: | 7072 |
NCBI Accession: | P31483.3 |
UniProt Related Accession: | P31483 |
Molecular Weight: | 43kDa |
NCBI Full Name: | Nucleolysin TIA-1 isoform p40 |
NCBI Synonym Full Names: | TIA1 cytotoxic granule associated RNA binding protein |
NCBI Official Symbol: | TIA1 |
NCBI Official Synonym Symbols: | WDM; TIA-1 |
NCBI Protein Information: | nucleolysin TIA-1 isoform p40; nucleolysin TIA-1 |
UniProt Protein Name: | Nucleolysin TIA-1 isoform p40 |
UniProt Synonym Protein Names: | RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA-1; p40-TIA-1 |
Protein Family: | Nucleolysin |
UniProt Gene Name: | TIA1 |
UniProt Entry Name: | TIA1_HUMAN |
Antibodies |
Anti-TIA1 Antibody (CAB12517) |
Anti-TIA1 Antibody (CAB12523) |
Anti-TIA1 Antibody (CAB6237) |
TIA1 Antibody (PACO12749) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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