TGFBRAP1 Antibody, HRP conjugated (PACO38051)
- SKU:
- PACO38051
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | TGFBRAP1 Antibody, HRP conjugated (PACO38051) |
抗体コード: | PACO38051 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Transforming growth factor-β receptor-associated protein 1 protein (401-600AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-β and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. |
シノニム: | Transforming growth factor-β receptor-associated protein 1 (TGF-β receptor-associated protein 1) (TRAP-1) (TRAP1), TGFBRAP1 |
UniProt Protein Function: | TGFBRAP1: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Belongs to the TRAP1 family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q12.1 Cellular Component: early endosome; membrane Molecular Function:protein binding; SMAD binding; transforming growth factor beta receptor binding Biological Process: endosomal vesicle fusion; endosome to lysosome transport; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway |
NCBI Summary: | This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016] |
UniProt Code: | Q8WUH2 |
NCBI GenInfo Identifier: | 74730711 |
NCBI Gene ID: | 9392 |
NCBI Accession: | Q8WUH2.1 |
UniProt Secondary Accession: | Q8WUH2,O60466, A8K5R7, D3DVJ8, |
UniProt Related Accession: | Q8WUH2 |
Molecular Weight: | 97,158 Da |
NCBI Full Name: | Transforming growth factor-beta receptor-associated protein 1 |
NCBI Synonym Full Names: | transforming growth factor beta receptor associated protein 1 |
NCBI Official Symbol: | TGFBRAP1 |
NCBI Official Synonym Symbols: | VPS3; TRAP1; TRAP-1 |
NCBI Protein Information: | transforming growth factor-beta receptor-associated protein 1 |
UniProt Protein Name: | Transforming growth factor-beta receptor-associated protein 1 |
Protein Family: | Transforming growth factor-beta receptor-associated protein |
UniProt Gene Name: | TGFBRAP1 |
UniProt Entry Name: | TGFA1_HUMAN |