TESC Antibody (PACO12699)
- SKU:
- PACO12699
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TESC Antibody (PACO12699) |
抗体コード: | PACO12699 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human TESC |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | tescalcin;TESC;CHP3;FLJ20607;TSC ; |
UniProt Protein Function: | TESC: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. Belongs to the calcineurin regulatory subunit family. CHP subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q24.22 Cellular Component: cytoplasm; lamellipodium; nucleus; plasma membrane; ruffle Molecular Function:calcium ion binding; magnesium ion binding; phosphatase inhibitor activity; protein binding; protein homodimerization activity Biological Process: negative regulation of cell proliferation; positive regulation of granulocyte differentiation; positive regulation of megakaryocyte differentiation; positive regulation of sodium:hydrogen antiporter activity; positive regulation of transcription, DNA-dependent; protein maturation; protein stabilization; regulation of cell adhesion mediated by integrin |
UniProt Code: | Q96BS2 |
NCBI GenInfo Identifier: | 284018160 |
NCBI Gene ID: | 54997 |
NCBI Accession: | Q96BS2.3 |
UniProt Secondary Accession: | Q96BS2,Q9NWT9, F5H1Y5, |
UniProt Related Accession: | Q96BS2 |
Molecular Weight: | 21,521 Da |
NCBI Full Name: | Calcineurin B homologous protein 3 |
NCBI Synonym Full Names: | tescalcin |
NCBI Official Symbol: | TESC |
NCBI Official Synonym Symbols: | TSC; CHP3 |
NCBI Protein Information: | calcineurin B homologous protein 3 |
UniProt Protein Name: | Calcineurin B homologous protein 3 |
UniProt Synonym Protein Names: | Tescalcin; TSC |
Protein Family: | Calcineurin B homologous protein |
UniProt Gene Name: | TESC |
UniProt Entry Name: | CHP3_HUMAN |