TCEB1 Antibody (PACO12668)
- SKU:
- PACO12668
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TCEB1 Antibody (PACO12668) |
抗体コード: | PACO12668 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human TCEB1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C);TCEB1;SIII ; |
UniProt Protein Function: | TCEB1: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Belongs to the SKP1 family. |
UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 8q21.11 Cellular Component: cytosol; nucleoplasm Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: positive regulation of RNA elongation from RNA polymerase II promoter; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
UniProt Code: | Q15369 |
NCBI GenInfo Identifier: | 32699511 |
NCBI Gene ID: | 6921 |
NCBI Accession: | Q15369.1 |
UniProt Secondary Accession: | Q15369,Q567Q6, E5RGD9, |
UniProt Related Accession: | Q15369 |
Molecular Weight: | 10,832 Da |
NCBI Full Name: | Transcription elongation factor B polypeptide 1 |
NCBI Synonym Full Names: | transcription elongation factor B subunit 1 |
NCBI Official Symbol: | TCEB1 |
NCBI Official Synonym Symbols: | SIII; eloC |
NCBI Protein Information: | transcription elongation factor B polypeptide 1 |
UniProt Protein Name: | Transcription elongation factor B polypeptide 1 |
UniProt Synonym Protein Names: | Elongin 15 kDa subunit; Elongin-C; EloC; RNA polymerase II transcription factor SIII subunit C; SIII p15 |
Protein Family: | Transcription elongation factor B polypeptide |
UniProt Gene Name: | TCEB1 |
UniProt Entry Name: | ELOC_HUMAN |