SYT1 (Ab-309) Antibody (PACO22974)
- SKU:
- PACO22974
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SYT1 (Ab-309) Antibody (PACO22974) |
抗体コード: | PACO22974 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IF:1:100-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Peptide sequence around aa.307~311 (G-L-S-D-P) derived from Human Synaptotagmin 1. |
憲法: | Liquid |
ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from mouse brain and rat brain tissue using Synaptotagmin 1 (Ab-309) Antibody. | |
Immunofluorescence staining of methanol-fixed Hela cells using Synaptotagmin 1 (Ab-309) Antibody. |
バックグラウンド: | The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse |
シノニム: | SYT1; SytI; Synaptotagmin I; P65; SYT |
UniProt Protein Function: | SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle; Calcium-binding Chromosomal Location of Human Ortholog: 12cen-q21 Cellular Component: neuron projection; plasma membrane; synaptic vesicle; synaptic vesicle membrane Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; low-density lipoprotein receptor binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SNARE binding; syntaxin-1 binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; detection of calcium ion; glutamate secretion; neurotransmitter secretion; positive regulation of synaptic transmission; protein homooligomerization; regulation of calcium ion-dependent exocytosis; regulation of exocytosis; regulation of synaptic transmission, glutamatergic; synaptic transmission; synaptic vesicle endocytosis; vesicle fusion |
NCBI Summary: | The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010] |
UniProt Code: | P21579 |
NCBI GenInfo Identifier: | 135086 |
NCBI Gene ID: | 6857 |
NCBI Accession: | P21579.1 |
UniProt Secondary Accession: | P21579,Q6AI31, |
UniProt Related Accession: | P21579 |
Molecular Weight: | 47,573 Da |
NCBI Full Name: | Synaptotagmin-1 |
NCBI Synonym Full Names: | synaptotagmin 1 |
NCBI Official Symbol: | SYT1 |
NCBI Official Synonym Symbols: | P65; SYT; SVP65 |
NCBI Protein Information: | synaptotagmin-1 |
UniProt Protein Name: | Synaptotagmin-1 |
UniProt Synonym Protein Names: | Synaptotagmin I; SytI; p65 |
Protein Family: | Synaptotagmin |
UniProt Gene Name: | SYT1 |
UniProt Entry Name: | SYT1_HUMAN |