SULF1 Antibody, FITC conjugated (PACO46784)
- SKU:
- PACO46784
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | SULF1 Antibody, FITC conjugated (PACO46784) |
抗体コード: | PACO46784 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Extracellular sulfatase Sulf-1 protein (105-372AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. |
シノニム: | Extracellular sulfatase Sulf-1 (hSulf-1) (EC 3.1.6), SULF1, KIAA1077 |
UniProt Protein Function: | SULF1: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. Belongs to the sulfatase family. |
UniProt Protein Details: | Protein type:Hydrolase; EC 3.1.6.-; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 8q13.2 Cellular Component: cell surface; endoplasmic reticulum; extracellular space; Golgi apparatus; lipid raft; plasma membrane Molecular Function:arylsulfatase activity; N-acetylglucosamine-6-sulfatase activity Biological Process: cartilage development; chondrocyte development; embryonic skeletal development; esophagus smooth muscle contraction; glomerular basement membrane development; glomerular filtration; heparan sulfate proteoglycan metabolic process; kidney development; negative regulation of angiogenesis; negative regulation of cell migration; negative regulation of endothelial cell proliferation; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of BMP signaling pathway; positive regulation of Wnt receptor signaling pathway; regulation of fibroblast growth factor receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway |
NCBI Summary: | This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q8IWU6 |
NCBI GenInfo Identifier: | 33112447 |
NCBI Gene ID: | 23213 |
NCBI Accession: | Q8IWU6.1 |
UniProt Secondary Accession: | Q8IWU6,Q86YV8, Q8NCA2, Q9UPS5, |
UniProt Related Accession: | Q8IWU6 |
Molecular Weight: | 101027 Da |
NCBI Full Name: | Extracellular sulfatase Sulf-1 |
NCBI Synonym Full Names: | sulfatase 1 |
NCBI Official Symbol: | SULF1 |
NCBI Official Synonym Symbols: | SULF-1 |
NCBI Protein Information: | extracellular sulfatase Sulf-1 |
UniProt Protein Name: | Extracellular sulfatase Sulf-1 |
Protein Family: | Extracellular sulfatase |
UniProt Gene Name: | SULF1 |
UniProt Entry Name: | SULF1_HUMAN |