STX1A Antibody (PACO18948)
- SKU:
- PACO18948
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | STX1A Antibody (PACO18948) |
抗体コード: | PACO18948 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:15-1:50 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human STX1A |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18948(STX1A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO18948(STX1A Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18948(STX1A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
シノニム: | Syntaxin 1A (brain) |
UniProt Protein Function: | STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Cellular Component: actomyosin; cell junction; cytoplasmic vesicle; endomembrane system; integral to membrane; intracellular organelle; membrane; neuron projection; plasma membrane; protein complex; secretory granule; SNARE complex; synapse; synaptic vesicle; synaptic vesicle membrane; voltage-gated potassium channel complex Molecular Function:ATP-dependent protein binding; calcium channel inhibitor activity; calcium-dependent protein binding; chloride channel inhibitor activity; glycoprotein binding; kinase binding; myosin binding; myosin head/neck binding; protein binding; protein binding, bridging; protein domain specific binding; protein heterodimerization activity; protein N-terminus binding; SNAP receptor activity; SNARE binding Biological Process: calcium ion-dependent exocytosis; exocytosis; intracellular protein transport; neurotransmitter transport; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; positive regulation of exocytosis; positive regulation of neurotransmitter secretion; regulation of exocytosis; response to gravity; secretion by cell; synaptic vesicle fusion to presynaptic membrane; transport; vesicle docking; vesicle-mediated transport |
NCBI Summary: | This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
UniProt Code: | Q16623 |
NCBI GenInfo Identifier: | 2501084 |
NCBI Gene ID: | 6804 |
NCBI Accession: | Q16623.1 |
UniProt Secondary Accession: | Q16623,O35526, P32851, |
UniProt Related Accession: | Q16623 |
Molecular Weight: | 33,054 Da |
NCBI Full Name: | Syntaxin-1A |
NCBI Synonym Full Names: | syntaxin 1A |
NCBI Official Symbol: | STX1A |
NCBI Official Synonym Symbols: | STX1; HPC-1; P35-1; SYN1A |
NCBI Protein Information: | syntaxin-1A |
UniProt Protein Name: | Syntaxin-1A |
UniProt Synonym Protein Names: | Neuron-specific antigen HPC-1 |
Protein Family: | Syntaxin |
UniProt Gene Name: | Stx1a |
UniProt Entry Name: | STX1A_MOUSE |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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