STX11 Antibody (PACO12554)
- SKU:
- PACO12554
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | STX11 Antibody (PACO12554) |
抗体コード: | PACO12554 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human STX11 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | syntaxin 11;STX11;FHL4;HLH4;HPLH4 ;Syntaxin-11,SYX11,syntaxin11 |
UniProt Protein Function: | STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q24.2 Cellular Component: integral to membrane; plasma membrane; SNARE complex; synaptic vesicle Molecular Function:protein binding; SNARE binding Biological Process: intracellular protein transport; synaptic vesicle fusion to presynaptic membrane; vesicle docking Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4 |
NCBI Summary: | This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75558 |
NCBI GenInfo Identifier: | 6175047 |
NCBI Gene ID: | 8676 |
NCBI Accession: | O75558.1 |
UniProt Secondary Accession: | O75558,O75378, O95148, Q5TCL6, E1P598, |
UniProt Related Accession: | O75558 |
Molecular Weight: | 33,196 Da |
NCBI Full Name: | Syntaxin-11 |
NCBI Synonym Full Names: | syntaxin 11 |
NCBI Official Symbol: | STX11 |
NCBI Official Synonym Symbols: | FHL4; HLH4; HPLH4 |
NCBI Protein Information: | syntaxin-11 |
UniProt Protein Name: | Syntaxin-11 |
Protein Family: | Syntaxin |
UniProt Gene Name: | STX11 |
UniProt Entry Name: | STX11_HUMAN |