STAT6 Antibody (PACO12516)
- SKU:
- PACO12516
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | STAT6 Antibody (PACO12516) |
抗体コード: | PACO12516 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human STAT6 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | signal transducer and activator of transcription 6, interleukin-4 induced;STAT6;D12S1644;IL-4-STAT;STAT6B;STAT6C ; |
UniProt Protein Function: | STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nucleoplasm Molecular Function:identical protein binding; protein binding; protein phosphatase binding; signal transducer activity; transcription factor activity Biological Process: mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
UniProt Code: | P42226 |
NCBI GenInfo Identifier: | 1174459 |
NCBI Gene ID: | 6778 |
NCBI Accession: | P42226.1 |
UniProt Secondary Accession: | P42226,Q5FBW5, Q71UP4, A8K316, B7ZA27, F5GXI9, |
UniProt Related Accession: | P42226 |
Molecular Weight: | |
NCBI Full Name: | Signal transducer and activator of transcription 6 |
NCBI Synonym Full Names: | signal transducer and activator of transcription 6 |
NCBI Official Symbol: | STAT6 |
NCBI Official Synonym Symbols: | STAT6B; STAT6C; D12S1644; IL-4-STAT |
NCBI Protein Information: | signal transducer and activator of transcription 6 |
UniProt Protein Name: | Signal transducer and activator of transcription 6 |
UniProt Synonym Protein Names: | IL-4 Stat |
Protein Family: | Signal transducer and transcription activator |
UniProt Gene Name: | STAT6 |
UniProt Entry Name: | STAT6_HUMAN |