STAT2 Antibody, Biotin conjugated (PACO46249)
- SKU:
- PACO46249
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | STAT2 Antibody, Biotin conjugated (PACO46249) |
抗体コード: | PACO46249 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Signal transducer and activator of transcription 2 protein (571-851AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-α and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
シノニム: | Signal transducer and activator of transcription 2 (p113), STAT2 |
UniProt Protein Function: | STAT2: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:DNA binding; identical protein binding; protein binding; signal transducer activity; transcription factor activity Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; JAK-STAT cascade; positive regulation of defense response to virus by host; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction |
NCBI Summary: | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | P52630 |
NCBI GenInfo Identifier: | 1711552 |
NCBI Gene ID: | 6773 |
NCBI Accession: | P52630.1 |
UniProt Secondary Accession: | P52630,Q16430, Q16431, Q9UDL4, B4DLC7, G3V2M6, |
UniProt Related Accession: | P52630 |
Molecular Weight: | 97,457 Da |
NCBI Full Name: | Signal transducer and activator of transcription 2 |
NCBI Synonym Full Names: | signal transducer and activator of transcription 2 |
NCBI Official Symbol: | STAT2 |
NCBI Official Synonym Symbols: | P113; IMD44; ISGF-3; STAT113 |
NCBI Protein Information: | signal transducer and activator of transcription 2 |
UniProt Protein Name: | Signal transducer and activator of transcription 2 |
UniProt Synonym Protein Names: | p113 |
Protein Family: | Signal transducer and activator of transcription |
UniProt Gene Name: | STAT2 |
UniProt Entry Name: | STAT2_HUMAN |