STAM Antibody (PACO12501)
- SKU:
- PACO12501
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | STAM Antibody (PACO12501) |
抗体コード: | PACO12501 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human STAM |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1;STAM;DKFZp686J2352;STAM1 ; |
UniProt Protein Function: | STAM1: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 10p14-p13 Cellular Component: early endosome membrane; cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; intracellular protein transport; positive regulation of signal transduction; signal transduction; endosome transport |
NCBI Summary: | This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011] |
UniProt Code: | Q92783 |
NCBI GenInfo Identifier: | 71153545 |
NCBI Gene ID: | 8027 |
NCBI Accession: | Q92783.3 |
UniProt Related Accession: | Q92783 |
Molecular Weight: | |
NCBI Full Name: | Signal transducing adapter molecule 1 |
NCBI Synonym Full Names: | signal transducing adaptor molecule |
NCBI Official Symbol: | STAM |
NCBI Official Synonym Symbols: | STAM1; STAM-1 |
NCBI Protein Information: | signal transducing adapter molecule 1 |
UniProt Protein Name: | Signal transducing adapter molecule 1 |
Protein Family: | STAM-binding protein |
UniProt Gene Name: | STAM |
UniProt Entry Name: | STAM1_HUMAN |