SPIN2B Antibody (PACO15036)
- SKU:
- PACO15036
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SPIN2B Antibody (PACO15036) |
抗体コード: | PACO15036 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human SPIN2B |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: SP20 cells, Primary antibody: PACO15036(SPIN2B Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
バックグラウンド: | Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acid, of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal. |
シノニム: | Spindlin family, member 2B |
UniProt Protein Function: | SPIN2B: Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors. Belongs to the SPIN/STSY family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: Xp11.1 Cellular Component: nucleus Biological Process: regulation of cell cycle; apoptosis; gamete generation; cell cycle |
UniProt Code: | Q9BPZ2 |
NCBI GenInfo Identifier: | 23822181 |
NCBI Gene ID: | 474343 |
NCBI Accession: | Q9BPZ2.1 |
UniProt Secondary Accession: | Q9BPZ2,Q7Z2M0, |
UniProt Related Accession: | Q9BPZ2 |
Molecular Weight: | 258 |
NCBI Full Name: | Spindlin-2B |
NCBI Synonym Full Names: | spindlin family, member 2B |
NCBI Official Symbol: | SPIN2B |
NCBI Official Synonym Symbols: | SPIN-2; SPIN-2B; dJ323P24.2; SPIN2_duplicate |
NCBI Protein Information: | spindlin-2B; telomeric SPIN2 copy; spindlin-like protein 2B; spindlin family, member 2 duplicate |
UniProt Protein Name: | Spindlin-2B |
UniProt Synonym Protein Names: | Spindlin-like protein 2B; SPIN-2; SPIN-2B |
Protein Family: | Spindlin |
UniProt Gene Name: | SPIN2B |
UniProt Entry Name: | SPI2B_HUMAN |