SPHK2 Antibody (PACO15777)
- SKU:
- PACO15777
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SPHK2 Antibody (PACO15777) |
抗体コード: | PACO15777 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human SPHK2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15777(SPHK2 Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: PACO15777(SPHK2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15777(SPHK2 Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
シノニム: | sphingosine kinase 2 |
UniProt Protein Function: | SPHK2: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid Metabolism - sphingolipid; Kinase, lipid; EC 2.7.1.91 Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: membrane; lysosomal membrane; cytosol Molecular Function:D-erythro-sphingosine kinase activity; protein binding; Ras GTPase binding; sphinganine kinase activity; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity Biological Process: cell proliferation; blood vessel development; sphingolipid metabolic process; sphingolipid biosynthetic process; protein kinase C activation; positive regulation of cell proliferation; sphingosine metabolic process; sphinganine-1-phosphate biosynthetic process; brain development; lipid phosphorylation; negative regulation of apoptosis |
NCBI Summary: | This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q9NRA0 |
NCBI GenInfo Identifier: | 22001996 |
NCBI Gene ID: | 56848 |
NCBI Accession: | Q9NRA0.2 |
UniProt Secondary Accession: | Q9NRA0,Q9BRN1, Q9H0Q2, Q9NWU7, A0T4C8, B4DU87, |
UniProt Related Accession: | Q9NRA0 |
Molecular Weight: | 654 |
NCBI Full Name: | Sphingosine kinase 2 |
NCBI Synonym Full Names: | sphingosine kinase 2 |
NCBI Official Symbol: | SPHK2 |
NCBI Official Synonym Symbols: | SK 2; SK-2; SPK 2; SPK-2 |
NCBI Protein Information: | sphingosine kinase 2; sphingosine kinase type 2 |
UniProt Protein Name: | Sphingosine kinase 2 |
Protein Family: | Sphingosine kinase |
UniProt Gene Name: | SPHK2 |
UniProt Entry Name: | SPHK2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |