SPAG6 Antibody (PACO18686)
- SKU:
- PACO18686
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SPAG6 Antibody (PACO18686) |
抗体コード: | PACO18686 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human SPAG6 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18686(SPAG6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18686(SPAG6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. |
シノニム: | sperm associated antigen 6 |
UniProt Protein Function: | SPAG6: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 10p12.2 Cellular Component: axoneme; microtubule cytoskeleton; nucleus Biological Process: spermatid development |
NCBI Summary: | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | O75602 |
NCBI GenInfo Identifier: | 62901067 |
NCBI Gene ID: | 9576 |
NCBI Accession: | O75602.1 |
UniProt Secondary Accession: | O75602,Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6, A8K1I8 B4DXZ4, |
UniProt Related Accession: | O75602 |
Molecular Weight: | 52,466 Da |
NCBI Full Name: | Sperm-associated antigen 6 |
NCBI Synonym Full Names: | sperm associated antigen 6 |
NCBI Official Symbol: | SPAG6 |
NCBI Official Synonym Symbols: | pf16; CT141; Repro-SA-1 |
NCBI Protein Information: | sperm-associated antigen 6 |
UniProt Protein Name: | Sperm-associated antigen 6 |
UniProt Synonym Protein Names: | Protein PF16 homolog; Repro-SA-1; Sperm flagellar protein |
Protein Family: | Sperm-associated antigen |
UniProt Gene Name: | SPAG6 |
UniProt Entry Name: | SPAG6_HUMAN |