SPAG5 Antibody (PACO43837)
- SKU:
- PACO43837
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SPAG5 Antibody (PACO43837) |
抗体コード: | PACO43837 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Sperm-associated antigen 5 protein (1-300AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43837 at dilution of 1:100. |
バックグラウンド: | Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU. |
シノニム: | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126), SPAG5 |
UniProt Protein Function: | SPAG5: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: kinetochore; spindle microtubule Molecular Function:protein binding Biological Process: chromosome segregation; establishment of spindle orientation; mitotic sister chromatid segregation; regulation of attachment of spindle microtubules to kinetochore; spindle organization and biogenesis |
NCBI Summary: | This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96R06 |
NCBI GenInfo Identifier: | 47117278 |
NCBI Gene ID: | 10615 |
NCBI Accession: | Q96R06.2 |
UniProt Secondary Accession: | Q96R06,O95213, Q9BWE8, Q9NT17, Q9UFE6, |
UniProt Related Accession: | Q96R06 |
Molecular Weight: | 134,422 Da |
NCBI Full Name: | Sperm-associated antigen 5 |
NCBI Synonym Full Names: | sperm associated antigen 5 |
NCBI Official Symbol: | SPAG5 |
NCBI Official Synonym Symbols: | MAP126; DEEPEST; hMAP126 |
NCBI Protein Information: | sperm-associated antigen 5 |
UniProt Protein Name: | Sperm-associated antigen 5 |
UniProt Synonym Protein Names: | Astrin; Deepest; Mitotic spindle-associated protein p126; MAP126 |
Protein Family: | Sperm-associated antigen |
UniProt Gene Name: | SPAG5 |
Antibodies | ELISA Kits |
Anti-SPAG5 Antibody (CAB6451) | Human SPAG5(sperm associated antigen 5) ELISA Kit |
SPAG5 Antibody (PACO12413) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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