SMUG1 Antibody (PACO03722)
- SKU:
- PACO03722
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SMUG1 Antibody |
抗体コード: | PACO03722 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat, Monkey |
免疫原: | synthesized peptide derived from the Internal region of human SMUG1. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | SMUG1; Single-strand selective monofunctional uracil DNA glycosylase |
UniProt Protein Function: | SMUG1: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.2.2.-; Hydrolase; DNA repair, damage Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: nucleolus; nucleoplasm Molecular Function:DNA N-glycosylase activity; oxidized pyrimidine base lesion DNA N-glycosylase activity; protein binding; single-strand selective uracil DNA N-glycosylase activity; uracil DNA N-glycosylase activity Biological Process: base-excision repair; depyrimidination |
NCBI Summary: | This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q53HV7 |
NCBI GenInfo Identifier: | 116242793 |
NCBI Gene ID: | 23583 |
NCBI Accession: | Q53HV7.2 |
UniProt Secondary Accession: | Q53HV7,O95862, Q0D2M0, Q8NB71, Q9BWC8, A8K2K9, |
UniProt Related Accession: | Q53HV7 |
Molecular Weight: | 19,627 Da |
NCBI Full Name: | Single-strand selective monofunctional uracil DNA glycosylase |
NCBI Synonym Full Names: | single-strand-selective monofunctional uracil-DNA glycosylase 1 |
NCBI Official Symbol: | SMUG1 |
NCBI Official Synonym Symbols: | FDG; UNG3; HMUDG |
NCBI Protein Information: | single-strand selective monofunctional uracil DNA glycosylase |
UniProt Protein Name: | Single-strand selective monofunctional uracil DNA glycosylase |
Protein Family: | Single-strand selective monofunctional uracil DNA glycosylase |
UniProt Gene Name: | SMUG1 |
UniProt Entry Name: | SMUG1_HUMAN |