SMC2 Antibody (PACO62375)
- SKU:
- PACO62375
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SMC2 Antibody (PACO62375) |
抗体コード: | PACO62375 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Structural maintenance of chromosomes protein 2 protein (861-968AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescence staining of HepG2 cells with PACO62375 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. |
シノニム: | Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog), SMC2, CAPE SMC2L1 |
UniProt Protein Function: | SMC2L1: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Belongs to the SMC family. SMC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 9q31.1 Cellular Component: condensed chromosome; condensin complex; cytoplasm; cytosol; nuclear chromosome; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: mitotic chromosome condensation |
UniProt Code: | O95347 |
NCBI GenInfo Identifier: | 215273886 |
NCBI Gene ID: | 10592 |
NCBI Accession: | O95347.2 |
UniProt Secondary Accession: | O95347,Q6IEE0, Q9P1P2, |
UniProt Related Accession: | O95347 |
Molecular Weight: | 124,926 Da |
NCBI Full Name: | Structural maintenance of chromosomes protein 2 |
NCBI Synonym Full Names: | structural maintenance of chromosomes 2 |
NCBI Official Symbol: | SMC2 |
NCBI Official Synonym Symbols: | CAPE; CAP-E; SMC-2; SMC2L1 |
NCBI Protein Information: | structural maintenance of chromosomes protein 2 |
UniProt Protein Name: | Structural maintenance of chromosomes protein 2 |
UniProt Synonym Protein Names: | Chromosome-associated protein E; hCAP-E; XCAP-E homolog |
UniProt Gene Name: | SMC2 |
UniProt Entry Name: | SMC2_HUMAN |
Antibodies |
Anti-SMC2 Antibody (CAB17867) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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