SLC8A2 Antibody (PACO18736)
- SKU:
- PACO18736
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SLC8A2 Antibody (PACO18736) |
抗体コード: | PACO18736 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human, Rat |
免疫原: | Synthetic peptide of human SLC8A2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18736(SLC8A2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18736(SLC8A2 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized. |
シノニム: | solute carrier family 8 (sodium/calcium exchanger), member 2 |
UniProt Protein Function: | Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca2+ and Na+ excretion. |
UniProt Code: | Q9UPR5 |
NCBI GenInfo Identifier: | 57163987 |
NCBI Gene ID: | 6543 |
NCBI Accession: | NP_055878.1 |
UniProt Secondary Accession: | Q9UPR5,B4DYQ9, |
UniProt Related Accession: | Q9UPR5 |
Molecular Weight: | 101 |
NCBI Full Name: | sodium/calcium exchanger 2 |
NCBI Synonym Full Names: | solute carrier family 8 member A2 |
NCBI Official Symbol: | SLC8A2 |
NCBI Official Synonym Symbols: | NCX2 |
NCBI Protein Information: | sodium/calcium exchanger 2 |
UniProt Protein Name: | Sodium/calcium exchanger 2 |
UniProt Synonym Protein Names: | Na(+)/Ca(2+)-exchange protein 2; Solute carrier family 8 member 2 |
Protein Family: | PsbD mRNA maturation factor |
UniProt Gene Name: | SLC8A2 |
Antibodies |
Anti-SLC8A2 Antibody (CAB15723) |
Secondary Antibody |
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