SLC6A3 Antibody (PACO48470)
- SKU:
- PACO48470
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SLC6A3 Antibody (PACO48470) |
抗体コード: | PACO48470 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Sodium-dependent dopamine transporter protein (161-237AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: SLC6A3 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 69 kDa. Observed band size: 69 kDa.. | |
Immunofluorescent analysis of HepG2 cells using PACO48470 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. |
シノニム: | Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3), SLC6A3, DAT1 |
UniProt Protein Function: | DAT: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI). It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. |
UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 5p15.3 Cellular Component: axon; cell soma; cell surface; cytoplasm; flotillin complex; integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:dopamine binding; dopamine transmembrane transporter activity; dopamine:sodium symporter activity; drug binding; monoamine transmembrane transporter activity; protease binding; protein binding; protein complex binding; protein N-terminus binding; protein phosphatase 2A binding; receptor binding Biological Process: adenohypophysis development; aging; dopamine biosynthetic process; dopamine catabolic process; dopamine transport; dopamine uptake; lactation; locomotory behavior; monoamine transport; neurotransmitter biosynthetic process; positive regulation of multicellular organism growth; prepulse inhibition; regulation of dopamine metabolic process; response to cAMP; response to cocaine; response to drug; response to ethanol; response to iron ion; response to nicotine; sensory perception of smell; synaptic transmission; transmembrane transport Disease: Parkinsonism-dystonia, Infantile; Tobacco Addiction, Susceptibility To |
NCBI Summary: | This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009] |
UniProt Code: | Q01959 |
NCBI GenInfo Identifier: | 7108463 |
NCBI Gene ID: | 6531 |
NCBI Accession: | AAC50179.2 |
UniProt Secondary Accession: | Q01959,Q14996, A2RUN4, |
UniProt Related Accession: | Q01959 |
Molecular Weight: | 68,495 Da |
NCBI Full Name: | dopamine transporter |
NCBI Synonym Full Names: | solute carrier family 6 (neurotransmitter transporter), member 3 |
NCBI Official Symbol: | SLC6A3 |
NCBI Official Synonym Symbols: | DAT; DAT1; PKDYS |
NCBI Protein Information: | sodium-dependent dopamine transporter |
UniProt Protein Name: | Sodium-dependent dopamine transporter |
UniProt Synonym Protein Names: | Solute carrier family 6 member 3 |
Protein Family: | D-alanine aminotransferase |
UniProt Gene Name: | SLC6A3 |
UniProt Entry Name: | SC6A3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |