SLC6A1 Antibody (PACO19683)
- SKU:
- PACO19683
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SLC6A1 Antibody (PACO19683) |
抗体コード: | PACO19683 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human SLC6A1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19683(SLC6A1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: PACO19683(SLC6A1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19683(SLC6A1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The SLC6A1 gene encodes a gamma-aminobutyric acid, (GABA) transporter, which removes GABA from the synaptic cleft.The cDNA contained an open reading frame encoding a hydrophobic protein of 599 amino acid, with a calculated molecular weight of 67,022 daltons. Hydropathy analysis showed 12 potential transmembrane segments. The human protein is highly homologous to that from rat brain |
シノニム: | solute carrier family 6 (neurotransmitter transporter), member 1 |
UniProt Protein Function: | SLC6A1: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: cell surface; membrane; integral to plasma membrane; axon; integral to membrane; plasma membrane Molecular Function:gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity Biological Process: response to purine; response to toxin; neurotransmitter secretion; learning; response to cocaine; response to estradiol stimulus; response to sucrose stimulus; synaptic transmission; transport; response to lead ion; gamma-aminobutyric acid import; negative regulation of synaptic transmission, GABAergic; response to calcium ion; transmembrane transport; protein homooligomerization; positive regulation of gamma-aminobutyric acid secretion Disease: Myoclonic-atonic Epilepsy |
NCBI Summary: | The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009] |
UniProt Code: | P30531 |
NCBI GenInfo Identifier: | 229462780 |
NCBI Gene ID: | 6529 |
NCBI Accession: | P30531.2 |
UniProt Secondary Accession: | P30531,Q8N4K8, |
UniProt Related Accession: | P30531 |
Molecular Weight: | 67,074 Da |
NCBI Full Name: | Sodium- and chloride-dependent GABA transporter 1 |
NCBI Synonym Full Names: | solute carrier family 6 (neurotransmitter transporter), member 1 |
NCBI Official Symbol: | SLC6A1 |
NCBI Official Synonym Symbols: | GAT1; GABATR; GABATHG |
NCBI Protein Information: | sodium- and chloride-dependent GABA transporter 1; GAT-1; solute carrier family 6 member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1 |
UniProt Protein Name: | Sodium- and chloride-dependent GABA transporter 1 |
UniProt Synonym Protein Names: | Solute carrier family 6 member 1 |
Protein Family: | Sodium- and chloride-dependent GABA transporter |
UniProt Gene Name: | SLC6A1 |
UniProt Entry Name: | SC6A1_HUMAN |
Antibodies |
Anti-SLC6A1 Antibody (CAB15099) |
Anti-SLC6A1 Antibody (CAB7730) |
SLC6A1 Antibody (PACO05076) |
SLC6A1 Antibody (PACO07178) |
SLC6A1 Antibody (PACO07311) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |