SLC40A1 Antibody, Biotin conjugated (PACO51017)
- SKU:
- PACO51017
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SLC40A1 Antibody, Biotin conjugated (PACO51017) |
抗体コード: | PACO51017 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Solute carrier family 40 member 1 protein (148-298AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). |
シノニム: | Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1), SLC40A1, FPN1 IREG1 SLC11A3 |
UniProt Protein Function: | SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family Chromosomal Location of Human Ortholog: 2q32 Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular Molecular Function:iron ion transmembrane transporter activity; protein binding Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; lymphocyte homeostasis; transmembrane transport; negative regulation of apoptosis Disease: Hemochromatosis, Type 4 |
NCBI Summary: | The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NP59 |
NCBI GenInfo Identifier: | 67633296 |
NCBI Gene ID: | 30061 |
NCBI Accession: | AAY78556.1 |
UniProt Secondary Accession: | Q9NP59,Q6FI62, Q7Z4F8, Q8IVB2, Q9NRL0, |
UniProt Related Accession: | Q9NP59 |
Molecular Weight: | 62,542 Da |
NCBI Full Name: | ferroportin 1 variant I, partial |
NCBI Synonym Full Names: | solute carrier family 40 (iron-regulated transporter), member 1 |
NCBI Official Symbol: | SLC40A1 |
NCBI Official Synonym Symbols: | FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3 |
NCBI Protein Information: | solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 |
UniProt Protein Name: | Solute carrier family 40 member 1 |
UniProt Synonym Protein Names: | Ferroportin-1; Iron-regulated transporter 1 |
UniProt Gene Name: | SLC40A1 |
UniProt Entry Name: | S40A1_HUMAN |