SLC26A4 Antibody, HRP conjugated (PACO57973)
- SKU:
- PACO57973
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | SLC26A4 Antibody, HRP conjugated (PACO57973) |
抗体コード: | PACO57973 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Pendrin protein (592-655AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Sodium-independent transporter of chloride and iodide. |
シノニム: | Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4), SLC26A4, PDS |
UniProt Protein Function: | SLC26A4: Sodium-independent transporter of chloride and iodide. Defects in SLC26A4 are a cause of Pendred syndrome (PDS). PDS is an autosomal recessive disorder characterized by congenital sensorineural hearing loss combined with thyroid goiter. The disorder may account for up to 10% of the cases of hereditary deafness. The deafness is most often associated with a Mondini cochlear defect. Defects in SLC26A4 are the cause of deafness autosomal recessive type 4 (DFNB4); also known as vestibular aqueduct syndrome (EVA). DFNB4 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB4 is associated with an enlarged vestibular aqueduct. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q31 Cellular Component: apical plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; iodide transmembrane transporter activity; oxalate transmembrane transporter activity; sulfate transmembrane transporter activity Biological Process: bicarbonate transport; inorganic anion transport; ion transport; regulation of intracellular pH; regulation of membrane potential; regulation of pH; regulation of protein localization; sensory perception of sound; sulfate transport Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome |
NCBI Summary: | Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43511 |
NCBI GenInfo Identifier: | 6174895 |
NCBI Gene ID: | 5172 |
NCBI Accession: | O43511.1 |
UniProt Secondary Accession: | O43511,O43170, B7Z266, |
UniProt Related Accession: | O43511 |
Molecular Weight: | 39,267 Da |
NCBI Full Name: | Pendrin |
NCBI Synonym Full Names: | solute carrier family 26 member 4 |
NCBI Official Symbol: | SLC26A4 |
NCBI Official Synonym Symbols: | EVA; PDS; DFNB4; TDH2B |
NCBI Protein Information: | pendrin |
UniProt Protein Name: | Pendrin |
UniProt Synonym Protein Names: | Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 |
Protein Family: | Pendrin |
UniProt Gene Name: | SLC26A4 |
UniProt Entry Name: | S26A4_HUMAN |