SLC26A2 Antibody (PACO59888)
- SKU:
- PACO59888
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SLC26A2 Antibody (PACO59888) |
抗体コード: | PACO59888 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Sulfate transporter protein (614-739AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO59888 diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
Immunofluorescence staining of HepG2 cells with PACO59888 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
IHC image of PACO59888 diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Sulfate transporter. May play a role in endochondral bone formation. |
シノニム: | Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2), SLC26A2, DTD DTDST |
UniProt Protein Function: | SLC26A2: Sulfate transporter. May play a role in endochondral bone formation. Defects in SLC26A2 are the cause of diastrophic dysplasia (DTD). DTD is an autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities. Defects in SLC26A2 are the cause of achondrogenesis type 1B (ACG1B). ACG1B is a recessively inherited chondrodysplasia characterized by extremely poor skeletal development and perinatal death. Defects in SLC26A2 are the cause of atelosteogenesis type 2 (AO2); also known as neonatal osseous dysplasia 1. AO2 is characterized by severely shortened limbs, small chest, scoliosis, club foot of the equinovarus type (talipes equinovarus), abducted thumbs and great toes, and cleft palate. Patients die of respiratory insufficiency shortly after birth because of the collapse of the airways and pulmonary hypoplasia due to the small rib cage. Defects in SLC26A2 are the cause of multiple epiphyseal dysplasia type 4 (EDM4). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature in EDM4 patients is not frequent. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q31-q34 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity Biological Process: ossification; glycosaminoglycan metabolic process; xenobiotic metabolic process; carbohydrate metabolic process; sulfate transport; ion transport; pathogenesis; transmembrane transport; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Disease: Atelosteogenesis, Type Ii; Diastrophic Dysplasia; Achondrogenesis, Type Ib; Epiphyseal Dysplasia, Multiple, 4 |
NCBI Summary: | The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50443 |
NCBI GenInfo Identifier: | 254763328 |
NCBI Gene ID: | 1836 |
NCBI Accession: | P50443.2 |
UniProt Secondary Accession: | P50443,Q6N051, A8K2U3, B2R6J1, |
UniProt Related Accession: | P50443 |
Molecular Weight: | 739 |
NCBI Full Name: | Sulfate transporter |
NCBI Synonym Full Names: | solute carrier family 26 (anion exchanger), member 2 |
NCBI Official Symbol: | SLC26A2 |
NCBI Official Synonym Symbols: | DTD; EDM4; DTDST; MST153; D5S1708; MSTP157 |
NCBI Protein Information: | sulfate transporter; sulfate anion transporter 1; diastrophic dysplasia protein; solute carrier family 26 (sulfate transporter), member 2 |
UniProt Protein Name: | Sulfate transporter |
UniProt Synonym Protein Names: | Diastrophic dysplasia protein; Solute carrier family 26 member 2 |
Protein Family: | Sulfate transporter |
UniProt Gene Name: | SLC26A2 |
UniProt Entry Name: | S26A2_HUMAN |