SLC22A2 Antibody (PACO53046)
- SKU:
- PACO53046
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SLC22A2 Antibody (PACO53046) |
抗体コード: | PACO53046 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human Solute carrier family 22 member 2 protein (48-135AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse kidney tissue, Rat heart tissue, Rat liver tissue, Rat lung tissue. All lanes: SLC22A2 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 63, 55, 27 kDa. Observed band size: 63 kDa. | |
Immunohistochemistry of paraffin-embedded human glioma using PACO53046 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO53046 at dilution of 1:100. |
バックグラウンド: | Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. |
シノニム: | Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2), SLC22A2, OCT2 |
UniProt Protein Function: | SLC22A2: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: membrane; plasma membrane Molecular Function:choline transmembrane transporter activity; dopamine transmembrane transporter activity; neurotransmitter transporter activity; organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity Biological Process: body fluid secretion; choline transport; dopamine transport; multidrug transport; neurotransmitter biosynthetic process; neurotransmitter secretion; organic cation transport |
NCBI Summary: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008] |
UniProt Code: | O15244 |
NCBI GenInfo Identifier: | 313104182 |
NCBI Gene ID: | 6582 |
NCBI Accession: | O15244.2 |
UniProt Secondary Accession: | O15244,Q5T7Q6, Q6PIQ8, Q8NG62, Q9NQB9, |
UniProt Related Accession: | O15244 |
Molecular Weight: | 26,685 Da |
NCBI Full Name: | Solute carrier family 22 member 2 |
NCBI Synonym Full Names: | solute carrier family 22 member 2 |
NCBI Official Symbol: | SLC22A2 |
NCBI Official Synonym Symbols: | OCT2 |
NCBI Protein Information: | solute carrier family 22 member 2 |
UniProt Protein Name: | Solute carrier family 22 member 2 |
UniProt Synonym Protein Names: | Organic cation transporter 2; hOCT2 |
Protein Family: | Solute carrier family |
UniProt Gene Name: | SLC22A2 |
UniProt Entry Name: | S22A2_HUMAN |