SLC1A3 Antibody, HRP conjugated (PACO64516)
- SKU:
- PACO64516
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SLC1A3 Antibody, HRP conjugated (PACO64516) |
抗体コード: | PACO64516 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Excitatory amino acid, transporter 1 protein (146-236AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Sodium-dependent, high-affinity amino acid, transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid, molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid, transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). |
シノニム: | Excitatory amino acid, transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3), SLC1A3, EAAT1 GLAST GLAST1 |
UniProt Protein Function: | SLC1A3: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 5p13 Cellular Component: membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity Biological Process: glutamate secretion; ion transport; L-glutamate import; neurotransmitter uptake; positive regulation of defense response to virus by host; synaptic transmission Disease: Episodic Ataxia, Type 6 |
NCBI Summary: | This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014] |
UniProt Code: | P43003 |
NCBI GenInfo Identifier: | 262359914 |
NCBI Gene ID: | 6507 |
NCBI Accession: | NP_001160167.1 |
UniProt Secondary Accession: | P43003,Q4JCQ8, B2R5T3, |
UniProt Related Accession: | P43003 |
Molecular Weight: | |
NCBI Full Name: | excitatory amino acid transporter 1 isoform 2 |
NCBI Synonym Full Names: | solute carrier family 1 member 3 |
NCBI Official Symbol: | SLC1A3 |
NCBI Official Synonym Symbols: | EA6; EAAT1; GLAST; GLAST1 |
NCBI Protein Information: | excitatory amino acid transporter 1 |
UniProt Protein Name: | Excitatory amino acid transporter 1 |
UniProt Synonym Protein Names: | Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 |
Protein Family: | Excitatory amino acid transporter |
UniProt Gene Name: | SLC1A3 |
UniProt Entry Name: | EAA1_HUMAN |