UniProt Protein Function: | SIRT5: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. Belongs to the sirtuin family. Class III subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; EC 3.5.1.-; Deacetylase Chromosomal Location of Human Ortholog: 6p23 Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial intermembrane space; cytosol; nucleus Molecular Function:zinc ion binding; NAD+ ADP-ribosyltransferase activity Biological Process: protein amino acid ADP-ribosylation; protein amino acid deacetylation; chromatin silencing |
NCBI Summary: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010] |
UniProt Code: | Q9NXA8 |
NCBI GenInfo Identifier: | 38258652 |
NCBI Gene ID: | 23408 |
NCBI Accession: | Q9NXA8.2 |
UniProt Secondary Accession: | Q9NXA8,Q5T294, Q5T295, Q9Y6E6, B4DFM4, B4DYJ5, F5H5Z9 |
UniProt Related Accession: | Q9NXA8 |
Molecular Weight: | 310 |
NCBI Full Name: | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
NCBI Synonym Full Names: | sirtuin 5 |
NCBI Official Symbol: | SIRT5 |
NCBI Official Synonym Symbols: | SIR2L5 |
NCBI Protein Information: | NAD-dependent protein deacylase sirtuin-5, mitochondrial; SIRT5; sir2-like 5; sirtuin type 5; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial |
UniProt Protein Name: | NAD-dependent protein deacylase sirtuin-5, mitochondrial |
UniProt Synonym Protein Names: | Regulatory protein SIR2 homolog 5; SIR2-like protein 5 |
Protein Family: | NAD-dependent protein deacylase sirtuin |
UniProt Gene Name: | SIRT5 |
UniProt Entry Name: | SIR5_HUMAN |