SIM2 Antibody, HRP conjugated (PACO57145)
- SKU:
- PACO57145
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SIM2 Antibody, HRP conjugated (PACO57145) |
抗体コード: | PACO57145 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Single-minded homolog 2 protein (347-433AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. |
シノニム: | Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15), SIM2, BHLHE15 |
UniProt Protein Function: | SIM2: Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 21q22.13 Cellular Component: nucleoplasm Molecular Function:signal transducer activity; DNA binding; protein heterodimerization activity; transcription factor activity Biological Process: nervous system development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; cell differentiation; signal transduction; lung development |
NCBI Summary: | This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
UniProt Code: | Q14190 |
NCBI GenInfo Identifier: | 2851630 |
NCBI Gene ID: | 6493 |
NCBI Accession: | Q14190.2 |
UniProt Related Accession: | Q14190 |
Molecular Weight: | 73kDa |
NCBI Full Name: | Single-minded homolog 2 |
NCBI Synonym Full Names: | SIM bHLH transcription factor 2 |
NCBI Official Symbol: | SIM2 |
NCBI Official Synonym Symbols: | SIM; bHLHe15; HMC13F06; HMC29C01 |
NCBI Protein Information: | single-minded homolog 2 |
UniProt Protein Name: | Single-minded homolog 2 |
UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 15; bHLHe15 |
Protein Family: | Single-minded |
UniProt Gene Name: | SIM2 |
UniProt Entry Name: | SIM2_HUMAN |