SIGLEC8 Antibody (PACO20461)
- SKU:
- PACO20461
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SIGLEC8 Antibody (PACO20461) |
抗体コード: | PACO20461 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human SIGLEC8 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20461(SIGLEC8 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20461(SIGLEC8 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Sialic acid, binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]). |
シノニム: | sialic acid, binding Ig-like lectin 8 |
UniProt Protein Function: | SIGLEC8: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.41 Molecular Function:protein binding; transmembrane receptor activity Biological Process: signal transduction |
NCBI Summary: | Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010] |
UniProt Code: | Q9NYZ4 |
NCBI GenInfo Identifier: | 25009268 |
NCBI Gene ID: | 27181 |
NCBI Accession: | Q9NYZ4.2 |
UniProt Secondary Accession: | Q9NYZ4,Q7Z728, |
UniProt Related Accession: | Q9NYZ4 |
Molecular Weight: | 54kDa |
NCBI Full Name: | Sialic acid-binding Ig-like lectin 8 |
NCBI Synonym Full Names: | sialic acid binding Ig like lectin 8 |
NCBI Official Symbol: | SIGLEC8 |
NCBI Official Synonym Symbols: | SAF2; SIGLEC-8; SIGLEC8L |
NCBI Protein Information: | sialic acid-binding Ig-like lectin 8 |
UniProt Protein Name: | Sialic acid-binding Ig-like lectin 8 |
UniProt Synonym Protein Names: | Sialoadhesin family member 2; SAF-2 |
Protein Family: | Sialic acid-binding Ig-like lectin |
UniProt Gene Name: | SIGLEC8 |
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