SIAH2 Antibody, Biotin conjugated (PACO58904)
- SKU:
- PACO58904
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SIAH2 Antibody, Biotin conjugated (PACO58904) |
抗体コード: | PACO58904 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase SIAH2 protein (1-72AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA. |
シノニム: | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2), SIAH2 |
NCBI Summary: | This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43255 |
NCBI GenInfo Identifier: | 31982899 |
NCBI Gene ID: | 6478 |
NCBI Accession: | NP_005058.3 |
UniProt Related Accession: | O43255 |
Molecular Weight: | 34kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase SIAH2 |
NCBI Synonym Full Names: | siah E3 ubiquitin protein ligase 2 |
NCBI Official Symbol: | SIAH2 |
NCBI Official Synonym Symbols: | hSiah2 |
NCBI Protein Information: | E3 ubiquitin-protein ligase SIAH2 |
UniProt Protein Name: | E3 ubiquitin-protein ligase SIAH2 |
UniProt Synonym Protein Names: | Seven in absentia homolog 2; Siah-2; hSiah2 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | SIAH2 |
UniProt Entry Name: | SIAH2_HUMAN |