SEPT12 Antibody (PACO37630)
- SKU:
- PACO37630
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SEPT12 Antibody (PACO37630) |
抗体コード: | PACO37630 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Septin-12 protein (1-358AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: A375 whole cell lysate, Mouse brain tissue. All lanes: SEPT12 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 41, 36 kDa. Observed band size: 41 kDa. | |
Immunofluorescent analysis of U251 cells using PACO37630 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). |
シノニム: | Septin-12, SEPT12 |
UniProt Protein Function: | SEPT12: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). Defects in SEPT12 are the cause of spermatogenic failure 10 (SPGF10). An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail. Belongs to the septin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Cytoskeletal; Hydrolase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cleavage furrow; microtubule cytoskeleton; midbody; perinuclear region of cytoplasm; spindle; stress fiber Molecular Function:GDP binding; GTP binding; phosphoinositide binding; protein binding; protein homodimerization activity Disease: Spermatogenic Failure 10 |
NCBI Summary: | This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q8IYM1 |
NCBI GenInfo Identifier: | 74750767 |
NCBI Gene ID: | 124404 |
NCBI Accession: | Q8IYM1.1 |
UniProt Secondary Accession: | Q8IYM1,Q0P6B0, Q1PBH0, Q96LL0, |
UniProt Related Accession: | Q8IYM1 |
Molecular Weight: | 35,191 Da |
NCBI Full Name: | Septin-12 |
NCBI Synonym Full Names: | septin 12 |
NCBI Official Symbol: | SEPT12 |
NCBI Official Synonym Symbols: | SPGF10 |
NCBI Protein Information: | septin-12 |
UniProt Protein Name: | Septin-12 |
UniProt Gene Name: | SEPT12 |
UniProt Entry Name: | SEP12_HUMAN |
Antibodies |
Anti-SEPT12 Antibody (CAB15564) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |