SEPSECS Antibody (PACO33456)
- SKU:
- PACO33456
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SEPSECS Antibody (PACO33456) |
抗体コード: | PACO33456 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human O-phosphoseryl-tRNA(Sec) selenium transferase protein (5-451AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: SEPSECS antibody at 2µg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 56, 6 kDa Observed band size: 56 kDa . | |
Immunofluorescent analysis of PC-3 cells using PACO33456 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO33456 at dilution of 1:100. |
バックグラウンド: | Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently |
シノニム: | O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Liver-pancreas antigen) (LP) (SLA-p35) (SLA/LP autoantigen) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (Soluble liver antigen) (SLA) (UGA suppressor tRNA-associated protein) (tRNA(Ser/Sec)-associated antigenic protein), SEPSECS, TRNP48 |
UniProt Protein Function: | SLA/LP: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Defects in SEPSECS are the cause of pontocerebellar hypoplasia type 2D (PCH2D). PCH2D is a disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures. Belongs to the SepSecS family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transferase; EC 2.9.1.2; RNA-binding Chromosomal Location of Human Ortholog: 4p15.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; transferase activity, transferring selenium-containing groups; tRNA binding; pyridoxal phosphate binding Biological Process: selenocysteine incorporation Disease: Pontocerebellar Hypoplasia, Type 2d |
NCBI Summary: | The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011] |
UniProt Code: | Q9HD40 |
NCBI GenInfo Identifier: | 62287911 |
NCBI Gene ID: | 51091 |
NCBI Accession: | Q9HD40.2 |
UniProt Secondary Accession: | Q9HD40,Q0D2P3, Q17RT1, Q9NXZ5, Q9UGM9, Q9Y353, A8K8W1 |
UniProt Related Accession: | Q9HD40 |
Molecular Weight: | 501 |
NCBI Full Name: | O-phosphoseryl-tRNA(Sec) selenium transferase |
NCBI Synonym Full Names: | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase |
NCBI Official Symbol: | SEPSECS |
NCBI Official Synonym Symbols: | LP; SLA; PCH2D; SLA/LP |
NCBI Protein Information: | O-phosphoseryl-tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; SLA-p35; SLA/LP autoantigen; soluble liver antigen; liver-pancreas antigen; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein; soluble liver antigen/liver pancreas antigen |
UniProt Protein Name: | O-phosphoseryl-tRNA(Sec) selenium transferase |
UniProt Synonym Protein Names: | Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein |
Protein Family: | O-phosphoseryl-tRNA(Sec) selenium transferase |
UniProt Gene Name: | SEPSECS |
UniProt Entry Name: | SPCS_HUMAN |
Antibodies | ELISA Kits |
Anti-SEPSECS Antibody (CAB7103) | Human O-phosphoseryl-tRNA(Sec) selenium transferase (SEPSECS) ELISA Kit |
SEPSECS Antibody (PACO12099) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |