SEMA7A Antibody (PACO20424)
- SKU:
- PACO20424
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SEMA7A Antibody (PACO20424) |
抗体コード: | PACO20424 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human SEMA7A |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20424(SEMA7A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: Mouse spleen tissue, Primary antibody: PACO20424(SEMA7A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20424(SEMA7A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene. |
シノニム: | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) |
UniProt Protein Function: | SEMA7A: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Belongs to the semaphorin family. |
UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 15q22.3-q23 Cellular Component: external side of plasma membrane; extracellular space; membrane; plasma membrane Molecular Function:chemorepellent activity; integrin binding; protein binding; semaphorin receptor binding Biological Process: immune response; integrin-mediated signaling pathway; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; osteoblast differentiation; positive regulation of axon extension; positive regulation of cell migration; regulation of inflammatory response Disease: Blood Group, John Milton Hagen System |
NCBI Summary: | This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] |
UniProt Code: | O75326 |
NCBI GenInfo Identifier: | 14548264 |
NCBI Gene ID: | 8482 |
NCBI Accession: | O75326.1 |
UniProt Secondary Accession: | O75326,Q1XE81, Q1XE82, Q1XE83, Q1XE84, Q3MIY5, B4DDP7 F5H1S0, |
UniProt Related Accession: | O75326 |
Molecular Weight: | 73,364 Da |
NCBI Full Name: | Semaphorin-7A |
NCBI Synonym Full Names: | semaphorin 7A (John Milton Hagen blood group) |
NCBI Official Symbol: | SEMA7A |
NCBI Official Synonym Symbols: | JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1 |
NCBI Protein Information: | semaphorin-7A |
UniProt Protein Name: | Semaphorin-7A |
UniProt Synonym Protein Names: | CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD_antigen: CD108 |
Protein Family: | Semaphorin |
UniProt Gene Name: | SEMA7A |
UniProt Entry Name: | SEM7A_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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