SEMA4C Antibody (PACO17067)
- SKU:
- PACO17067
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SEMA4C Antibody (PACO17067) |
抗体コード: | PACO17067 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human SEMA4C |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17067(SEMA4C Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17067(SEMA4C Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. |
シノニム: | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C |
UniProt Protein Function: | SEMA4C: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Belongs to the semaphorin family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q11.2 Cellular Component: extracellular space; membrane; postsynaptic density; synaptic vesicle membrane Molecular Function:chemorepellent activity; protein binding; semaphorin receptor binding Biological Process: cell migration in hindbrain; muscle cell differentiation; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; neural tube closure; positive regulation of cell migration; positive regulation of stress-activated MAPK cascade |
UniProt Code: | Q9C0C4 |
NCBI GenInfo Identifier: | 47606208 |
NCBI Gene ID: | 54910 |
NCBI Accession: | Q9C0C4.2 |
UniProt Secondary Accession: | Q9C0C4,Q32MJ3, Q7Z5X0, |
UniProt Related Accession: | Q9C0C4 |
Molecular Weight: | 92,623 Da |
NCBI Full Name: | Semaphorin-4C |
NCBI Synonym Full Names: | semaphorin 4C |
NCBI Official Symbol: | SEMA4C |
NCBI Official Synonym Symbols: | SEMAF; SEMAI; SEMACL1; M-SEMA-F |
NCBI Protein Information: | semaphorin-4C |
UniProt Protein Name: | Semaphorin-4C |
Protein Family: | Semaphorin |
UniProt Gene Name: | SEMA4C |
UniProt Entry Name: | SEM4C_HUMAN |