SCNN1A Antibody (PACO19278)
- SKU:
- PACO19278
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SCNN1A Antibody (PACO19278) |
抗体コード: | PACO19278 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human SCNN1A |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19278(SCNN1A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19278(SCNN1A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the α subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
シノニム: | sodium channel, non-voltage-gated 1 α subunit |
UniProt Protein Function: | ENaC-alpha: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter, ion channel; Membrane protein, multi-pass; Channel, sodium; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13 Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane Molecular Function:amiloride-sensitive sodium channel activity; protein binding; WW domain binding Biological Process: multicellular organismal water homeostasis; sodium ion homeostasis Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 2; Pseudohypoaldosteronism, Type I, Autosomal Recessive |
NCBI Summary: | Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009] |
UniProt Code: | P37088 |
NCBI GenInfo Identifier: | 585966 |
NCBI Gene ID: | 6337 |
NCBI Accession: | P37088.1 |
UniProt Secondary Accession: | P37088,O43271, Q6GSQ6, Q9UM64, A5X2U9, B4E2Q5, C5HTZ0 |
UniProt Related Accession: | P37088 |
Molecular Weight: | |
NCBI Full Name: | Amiloride-sensitive sodium channel subunit alpha |
NCBI Synonym Full Names: | sodium channel epithelial 1 alpha subunit |
NCBI Official Symbol: | SCNN1A |
NCBI Official Synonym Symbols: | BESC2; ENaCa; SCNEA; SCNN1; ENaCalpha |
NCBI Protein Information: | amiloride-sensitive sodium channel subunit alpha |
UniProt Protein Name: | Amiloride-sensitive sodium channel subunit alpha |
UniProt Synonym Protein Names: | Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; ENaCA; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA |
Protein Family: | Amiloride-sensitive sodium channel |
UniProt Gene Name: | SCNN1A |
UniProt Entry Name: | SCNNA_HUMAN |