SART3 Antibody (PACO20393)
- SKU:
- PACO20393
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SART3 Antibody (PACO20393) |
抗体コード: | PACO20393 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:20-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human SART3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20393(SART3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. |
シノニム: | squamous cell carcinoma antigen recognized by T cells 3 |
UniProt Protein Function: | SART3: a ubiquitously expressed protein in proliferating cells. A component of the 7SK snRNP complex composed of P-TEFb (composed of CDK9 and CCNT1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Transiently associates with the U6 and U4/U6 snRNPs during the spliceosome cycle, helping to regenerate functional U4/U6 snRNPs complexes. Expressed in the nucleus of all of malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas, adenocarcinomas, melanomas and leukemias. However, this protein is undetectable in the nucleus of nonmalignant cell lines or normal tissues, except for the testis. Expressed in the cytoplasm of all proliferating cells, including normal and malignant cells, but not in most cells of normal tissues, except for the testis and the fetal liver. Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; RNA-binding; Transcription regulation Chromosomal Location of Human Ortholog: 12q23.3 Cellular Component: Cajal body; nucleoplasm; nucleus; U4/U6 x U5 tri-snRNP complex Molecular Function:histone binding; protein binding; RNA binding; U4 snRNA binding; U6 snRNA binding; U6atac snRNA binding Biological Process: assembly of spliceosomal tri-snRNP; nuclear mRNA splicing, via spliceosome; nucleosome assembly; regulation of gene expression; spliceosomal snRNP biogenesis Disease: Porokeratosis 3, Disseminated Superficial Actinic Type |
NCBI Summary: | The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15020 |
NCBI GenInfo Identifier: | 74762140 |
NCBI Gene ID: | 9733 |
NCBI Accession: | Q15020.1 |
UniProt Secondary Accession: | Q15020,Q2M2H0, Q58F06, Q8IUS1, Q96J95, A8K2E4, B7ZKM0 |
UniProt Related Accession: | Q15020 |
Molecular Weight: | 110kDa |
NCBI Full Name: | Squamous cell carcinoma antigen recognized by T-cells 3 |
NCBI Synonym Full Names: | squamous cell carcinoma antigen recognized by T-cells 3 |
NCBI Official Symbol: | SART3 |
NCBI Official Synonym Symbols: | P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14 |
NCBI Protein Information: | squamous cell carcinoma antigen recognized by T-cells 3 |
UniProt Protein Name: | Squamous cell carcinoma antigen recognized by T-cells 3 |
UniProt Synonym Protein Names: | Tat-interacting protein of 110 kDa |
Protein Family: | Squamous cell carcinoma antigen |
UniProt Gene Name: | SART3 |