RUNX3 Antibody, Biotin conjugated (PACO51937)
- SKU:
- PACO51937
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | RUNX3 Antibody, Biotin conjugated (PACO51937) |
抗体コード: | PACO51937 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Runt-related transcription factor 3 protein (1-415AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-β stimulation. |
シノニム: | Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 α C subunit) (PEA2-α C) (PEBP2-α C) (SL3-3 enhancer factor 1 α C subunit) (SL3/AKV core-binding factor α C subunit), RUNX3, AML2 CBFA3 PEBP2A3 |
UniProt Protein Function: | AML2: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA- binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 1p36 Cellular Component: cytoplasm; nuclear chromatin; nucleus Molecular Function:protein binding; transcription factor activity Biological Process: chondrocyte differentiation; hemopoiesis; negative regulation of cell cycle; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; ossification; peripheral nervous system neuron development; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cell differentiation; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
UniProt Code: | Q13761 |
NCBI GenInfo Identifier: | 17368453 |
NCBI Gene ID: | 864 |
NCBI Accession: | Q13761.2 |
UniProt Secondary Accession: | Q13761,Q12969, Q13760, B1AJV5, |
UniProt Related Accession: | Q13761 |
Molecular Weight: | 45,922 Da |
NCBI Full Name: | Runt-related transcription factor 3 |
NCBI Synonym Full Names: | runt related transcription factor 3 |
NCBI Official Symbol: | RUNX3 |
NCBI Official Synonym Symbols: | AML2; CBFA3; PEBP2aC |
NCBI Protein Information: | runt-related transcription factor 3 |
UniProt Protein Name: | Runt-related transcription factor 3 |
UniProt Synonym Protein Names: | Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit |
Protein Family: | Runt-related transcription factor |
UniProt Gene Name: | RUNX3 |
UniProt Entry Name: | RUNX3_HUMAN |