RTKN Antibody (PACO44415)
- SKU:
- PACO44415
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RTKN Antibody (PACO44415) |
抗体コード: | PACO44415 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Rhotekin protein (304-563AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RTKN antibody at 4.66µg/ml. Lane 1: A431 whole cell lysate. Lane 2: HepG2 whole cell lysate. Lane 3: MCF-7 whole cell lysate. Lane 4: Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 63, 62, 57 kDa. Observed band size: 63 kDa.. | |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO44415 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44415 at dilution of 1:100. |
バックグラウンド: | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. |
シノニム: | Rhotekin, RTKN, RTKN1 |
UniProt Protein Function: | RTKN: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 2p13.1 Molecular Function:protein binding; GTP binding; GTP-Rho binding; GTPase inhibitor activity Biological Process: apoptosis; negative regulation of catalytic activity; signal transduction; Rho protein signal transduction |
NCBI Summary: | This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BST9 |
NCBI GenInfo Identifier: | 74733052 |
NCBI Gene ID: | 6242 |
NCBI Accession: | Q9BST9.2 |
UniProt Secondary Accession: | Q9BST9,Q8WVN1, Q96PT6, Q9HB05, H7BXD4, |
UniProt Related Accession: | Q9BST9 |
Molecular Weight: | 563 |
NCBI Full Name: | Rhotekin |
NCBI Synonym Full Names: | rhotekin |
NCBI Official Symbol: | RTKN |
NCBI Protein Information: | rhotekin; RTKN |
UniProt Protein Name: | Rhotekin |
Protein Family: | Rhotekin |
UniProt Gene Name: | RTKN |
UniProt Entry Name: | RTKN_HUMAN |