RNF6 Antibody, HRP conjugated (PACO52927)
- SKU:
- PACO52927
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | RNF6 Antibody, HRP conjugated (PACO52927) |
抗体コード: | PACO52927 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase RNF6 protein (1-298AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. |
シノニム: | E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF6), RNF6, SPG2 |
UniProt Protein Function: | RNF6: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Defects in RNF6 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the RNF12 family. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; Ligase Chromosomal Location of Human Ortholog: 13q12.2 Cellular Component: axon; cytoplasm; intracellular membrane-bound organelle; nuclear membrane; nucleoplasm; nucleus Molecular Function:androgen receptor binding; protein binding; ubiquitin-protein ligase activity Biological Process: negative regulation of axon extension; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of transcription, DNA-dependent; ubiquitin-dependent protein catabolic process Disease: Esophageal Cancer |
NCBI Summary: | The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y252 |
NCBI GenInfo Identifier: | 13124536 |
NCBI Gene ID: | 6049 |
NCBI Accession: | Q9Y252.1 |
UniProt Secondary Accession: | Q9Y252,Q5W0H0, Q9BZP5, Q9UF41, B4DDP0, |
UniProt Related Accession: | Q9Y252 |
Molecular Weight: | 16,680 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase RNF6 |
NCBI Synonym Full Names: | ring finger protein 6 |
NCBI Official Symbol: | RNF6 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RNF6 |
UniProt Protein Name: | E3 ubiquitin-protein ligase RNF6 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RNF6 |
UniProt Entry Name: | RNF6_HUMAN |