RFFL Antibody (PACO16967)
- SKU:
- PACO16967
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RFFL Antibody (PACO16967) |
抗体コード: | PACO16967 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human RFFL |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16967(RFFL Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. |
シノニム: | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
UniProt Protein Function: | RFFL: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Vesicle; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 17q12 Cellular Component: Golgi membrane; membrane; recycling endosome membrane; lysosome; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; endosome membrane; cytosol Molecular Function:protein binding; protease binding; zinc ion binding; p53 binding; ubiquitin protein ligase binding; protein kinase binding; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; intracellular protein transport; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway |
UniProt Code: | Q8WZ73 |
NCBI GenInfo Identifier: | 74760639 |
NCBI Gene ID: | 117584 |
NCBI Accession: | Q8WZ73.1 |
UniProt Secondary Accession: | Q8WZ73,Q8NHW0, Q8TBY7, Q96BE6, E1P633, |
UniProt Related Accession: | Q8WZ73 |
Molecular Weight: | 363 |
NCBI Full Name: | E3 ubiquitin-protein ligase rififylin |
NCBI Synonym Full Names: | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
NCBI Official Symbol: | RFFL |
NCBI Official Synonym Symbols: | CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN |
NCBI Protein Information: | E3 ubiquitin-protein ligase rififylin; RING finger protein 189; caspase regulator CARP2; FYVE-RING finger protein SAKURA; ring finger and FYVE-like domain containing 1; caspases-8 and -10-associated RING finger protein 2; RING finger and FYVE-like domain-containing protein 1 |
UniProt Protein Name: | E3 ubiquitin-protein ligase rififylin |
UniProt Synonym Protein Names: | Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; CARP-2; FYVE-RING finger protein Sakura; Fring; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RFFL |
UniProt Entry Name: | RFFL_HUMAN |