RFC1 Antibody (PACO02071)
- SKU:
- PACO02071
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | RFC1 Antibody |
抗体コード: | PACO02071 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | WB:1:500-1:2000 |
反応性: | Human |
免疫原: | synthesized peptide derived from the C-terminal region of human RFC1. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | RFC1; RFC140; Replication factor C subunit 1; Activator 1 140 kDa subunit; A1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; DNA-binding protein PO-GA |
UniProt Protein Function: | RFC1: a DNA binding protein that may play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and RFC1. The RFC1 subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 4p14-p13 Cellular Component: nucleoplasm; Golgi apparatus; DNA replication factor C complex; nucleolus; cell junction; nucleus Molecular Function:protein domain specific binding; protein binding; DNA binding; sequence-specific DNA binding; enzyme activator activity; double-stranded DNA binding; ATP binding; DNA clamp loader activity Biological Process: positive regulation of catalytic activity; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; telomere maintenance via telomerase; negative regulation of transcription from RNA polymerase II promoter; DNA strand elongation during DNA replication; DNA repair; telomere maintenance via semi-conservative replication; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; telomere maintenance via recombination; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; DNA-dependent DNA replication; telomere maintenance |
NCBI Summary: | This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011] |
UniProt Code: | P35251 |
NCBI GenInfo Identifier: | 56757608 |
NCBI Gene ID: | 5981 |
NCBI Accession: | P35251.4 |
UniProt Secondary Accession: | P35251,Q5XKF5, Q6PKU0, Q86V41, Q86V46, A8K6E7, |
UniProt Related Accession: | P35251 |
Molecular Weight: | 1148 |
NCBI Full Name: | Replication factor C subunit 1 |
NCBI Synonym Full Names: | replication factor C (activator 1) 1, 145kDa |
NCBI Official Symbol: | RFC1 |
NCBI Official Synonym Symbols: | A1; RFC; PO-GA; RECC1; MHCBFB; RFC140 |
NCBI Protein Information: | replication factor C subunit 1; A1 140 kDa subunit; RF-C 140 kDa subunit; activator 1 subunit 1; replication factor C1; MHC binding factor, beta; DNA-binding protein PO-GA; activator 1 large subunit; activator 1 140 kDa subunit; replication factor C large |
UniProt Protein Name: | Replication factor C subunit 1 |
UniProt Synonym Protein Names: | Activator 1 140 kDa subunit; A1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; DNA-binding protein PO-GA; Replication factor C 140 kDa subunit; RF-C 140 kDa subunit; RFC140; Replication factor C large subunit |
Protein Family: | O-antigen polymerase |
UniProt Gene Name: | RFC1 |
UniProt Entry Name: | RFC1_HUMAN |