RECK Antibody (PACO05513)
- SKU:
- PACO05513
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RECK Antibody (PACO05513) |
抗体コード: | PACO05513 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:20000, IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human, Mouse |
免疫原: | Synthesized peptide derived from the N-terminal region of human RECK. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | RECK; ST15; Reversion-inducing cysteine-rich protein with Kazal motifs; hRECK; Suppressor of tumorigenicity 15 protein |
UniProt Protein Function: | RECK: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Interacts with MMP-9. Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells. |
UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Tumor suppressor Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: membrane; plasma membrane Molecular Function:serine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding; endopeptidase inhibitor activity Biological Process: extracellular matrix organization and biogenesis; blood vessel maturation; embryo implantation |
NCBI Summary: | The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95980 |
NCBI GenInfo Identifier: | 20178043 |
NCBI Gene ID: | 8434 |
NCBI Accession: | O95980.1 |
UniProt Secondary Accession: | O95980,Q5W0K6, Q8WX37, B2RNS1, |
UniProt Related Accession: | O95980 |
Molecular Weight: | 971 |
NCBI Full Name: | Reversion-inducing cysteine-rich protein with Kazal motifs |
NCBI Synonym Full Names: | reversion-inducing-cysteine-rich protein with kazal motifs |
NCBI Official Symbol: | RECK |
NCBI Official Synonym Symbols: | ST15 |
NCBI Protein Information: | reversion-inducing cysteine-rich protein with Kazal motifs; suppressor of tumorigenicity 15 protein; membrane-anchored glycoprotein (metastasis and invasion); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs) |
UniProt Protein Name: | Reversion-inducing cysteine-rich protein with Kazal motifs |
UniProt Synonym Protein Names: | Suppressor of tumorigenicity 15 protein |
Protein Family: | Reversion-inducing cysteine-rich protein |
UniProt Gene Name: | RECK |
UniProt Entry Name: | RECK_HUMAN |