RCC1 Antibody (PACO20330)
- SKU:
- PACO20330
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RCC1 Antibody (PACO20330) |
抗体コード: | PACO20330 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human RCC1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Raji cells, Primary antibody: PACO20330(RCC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
バックグラウンド: | RCC1 (regulator of chromosome condensation 1), increases the rate at which Ran exchanges GDP for GTP. Ran GAP1 opposes the effects of RCC1 by increasing the rate at which Ran hydrolyzes GTP to GDP. A protein designated Ran BP1 has no intrinsic GAP activity and functions as a GEF inhibitor, deactivating RCC1 and thereby indirectly increasing the ratio of Ran GDP to Ran GTP. Ran BP2 has been proposed as the Ran GTP docking site at the periphery of the nuclear pore complex. |
シノニム: | regulator of chromosome condensation 1 |
UniProt Protein Function: | RCC1: a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs; GEFs, Ras; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p36.1 Cellular Component: nucleoplasm; nuclear membrane; condensed nuclear chromosome; cytoplasm; nuclear chromatin; nucleus Molecular Function:protein binding; nucleosomal DNA binding; Ran guanyl-nucleotide exchange factor activity; histone binding; chromatin binding Biological Process: mitosis; mitotic spindle organization and biogenesis; viral reproduction; cell division; regulation of mitosis; spindle assembly; G1/S transition of mitotic cell cycle; chromosome segregation |
UniProt Code: | P18754 |
NCBI GenInfo Identifier: | 132170 |
NCBI Gene ID: | 1104 |
NCBI Accession: | P18754.1 |
UniProt Secondary Accession: | P18754,Q16269, Q6NT97, |
UniProt Related Accession: | P18754 |
Molecular Weight: | 421 |
NCBI Full Name: | Regulator of chromosome condensation |
NCBI Synonym Full Names: | regulator of chromosome condensation 1 |
NCBI Official Symbol: | RCC1 |
NCBI Official Synonym Symbols: | CHC1; RCC1-I; SNHG3-RCC1 |
NCBI Protein Information: | regulator of chromosome condensation; SNHG3-RCC1 readthrough; cell cycle regulatory protein; guanine nucleotide-releasing protein |
UniProt Protein Name: | Regulator of chromosome condensation |
UniProt Synonym Protein Names: | Cell cycle regulatory protein; Chromosome condensation protein 1 |
Protein Family: | RCC1 domain-containing protein |
UniProt Gene Name: | RCC1 |
UniProt Entry Name: | RCC1_HUMAN |