RBP4 Antibody (PACO32316)
- SKU:
- PACO32316
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RBP4 Antibody (PACO32316) |
抗体コード: | PACO32316 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Retinol-binding protein 4 protein (19-201AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: RBP4 antibody at 2µg/ml Lane 1: Human positive serum at 1: 10 Lane 2: Human positive serum at 1: 100 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 24 kDa Observed band size: 24 kDa . | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO32316 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO32316 at dilution of 1:100. |
バックグラウンド: | Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. |
シノニム: | Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)], RBP4 |
UniProt Protein Function: | Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. |
UniProt Protein Details: | Subcellular location: Secreted. Involvement in Disease: Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [ MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Sequence similarities: Belongs to the calycin superfamily. Lipocalin family. Mass spectrometry: Molecular mass is 21063.46±1.88 Da from positions 17 - 199. Determined by ESI. Ref.10Molecular mass is 20534 Da from positions 19 - 197. Determined by MALDI. Ref.12Molecular mass is 20162 Da from positions 19 - 194. Determined by MALDI. Ref.12 Sequence caution: The sequence AAF69622.1 differs from that shown. Reason: Erroneous initiation. |
NCBI Summary: | This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq] |
UniProt Code: | P02753 |
NCBI GenInfo Identifier: | 62298174 |
NCBI Gene ID: | 5950 |
NCBI Accession: | P02753.3 |
UniProt Secondary Accession: | P02753,O43478, O43479, Q5VY24, Q8WWA3, Q9P178, D3DR38 |
UniProt Related Accession: | P02753 |
Molecular Weight: | 23,010 Da |
NCBI Full Name: | Retinol-binding protein 4 |
NCBI Synonym Full Names: | retinol binding protein 4, plasma |
NCBI Official Symbol: | RBP4 |
NCBI Protein Information: | retinol-binding protein 4; RBP; PRBP; OTTHUMP00000020114; OTTHUMP00000020115; OTTHUMP00000020116; plasma retinol-binding protein; retinol-binding protein 4, interstitial |
UniProt Protein Name: | Retinol-binding protein 4 |
UniProt Synonym Protein Names: | Plasma retinol-binding protein |
Protein Family: | Retinol-binding protein |
UniProt Gene Name: | RBP4 |
UniProt Entry Name: | RET4_HUMAN |
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